Regulation of mitochondrial KATP channel by redox agents
نویسندگان
چکیده
منابع مشابه
Neuroprotective Effect of Mitochondrial Katp Channel Opener Upon Neuronal Cortical Brain of Rat Population
Purpose: So far there is no effective drug therapy to prevent neuronal loss after brain stroke. In the present study we studied effects of The Mitochondrial K-ATP channel regulators on neuronal cell population and neurological function after ischemia reperfusion in the rat. Materials and Methods: Rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusi...
متن کاملRegulation of KATP Channel Activity by Diazoxide and MgADP
KATP channels were reconstituted in COSm6 cells by coexpression of the sulfonylurea receptor SUR1 and the inward rectifier potassium channel Kir6.2. The role of the two nucleotide binding folds of SUR1 in regulation of KATP channel activity by nucleotides and diazoxide was investigated. Mutations in the linker region and the Walker B motif (Walker, J.E., M.J. Saraste, M.J. Runswick, and N.J. Ga...
متن کاملState-dependent inhibition of the mitochondrial KATP channel by glyburide and 5-hydroxydecanoate.
The mitochondrial KATP channel (mitoKATP) is hypothesized to be the receptor for the cardioprotective effects of K+ channel openers (KCO) and for the blocking of cardioprotection by glyburide and 5-hydroxydecanoate (5-HD). Studies on glyburide have indicated that this drug is inactive in isolated mitochondria. No studies of the effects of 5-HD on isolated mitochondria have been reported. This p...
متن کاملFINAL ACCEPTED VERSION Mitochondrial KATP Channel Openers Activate the ERK Kinase by an Oxidant- Dependent Mechanism
Extracellular signal regulated kinases (ERKs) are key regulatory proteins that mediate cell survival, proliferation and differentiation. Reactive oxygen species (ROS) may play a role in activation of the ERK pathway. Since mitochondria are a major source of ROS, we investigated whether mitochondrial-derived ROS play a role in ERK activation. Diazoxide, a potent mitochondrial ATP-sensitive K + c...
متن کاملKir6.2 is not the mitochondrial KATP channel but is required for cardioprotection by ischemic preconditioning.
ATP-sensitive K(+) (KATP) channels that contain K(+) inward rectifier subunits of the 6.2 isotype (Kir6.2) are important regulators of the cardiac response to ischemia-reperfusion (I/R) injury. Opening of these channels is implicated in the cardioprotective mechanism of ischemic preconditioning (IPC), but debate surrounds the contribution of surface KATP (sKATP) versus mitochondrial KATP (mKATP...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Bioenergetics
سال: 1999
ISSN: 0005-2728
DOI: 10.1016/s0005-2728(98)00179-0